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    Home»Nanotechnology»Biomimetic gene delivery system coupled with extracellular vesicle–encapsulated AAV for improving diabetic wound through promoting vascularization and remodeling of inflammatory microenvironment | Journal of Nanobiotechnology
    Nanotechnology

    Biomimetic gene delivery system coupled with extracellular vesicle–encapsulated AAV for improving diabetic wound through promoting vascularization and remodeling of inflammatory microenvironment | Journal of Nanobiotechnology

    big tee tech hubBy big tee tech hubMarch 26, 20250012 Mins Read
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    Biomimetic gene delivery system coupled with extracellular vesicle–encapsulated AAV for improving diabetic wound through promoting vascularization and remodeling of inflammatory microenvironment | Journal of Nanobiotechnology
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  • Lee J, van der Valk WH, Serdy SA, Deakin C, Kim J, Le AP, Koehler KR. Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells. Nat Protoc. 2022;17(5):1266–305.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Matoori S, Veves A, Mooney DJ. Advanced bandages for diabetic wound healing. Sci Transl Med. 2021;13(585).

  • Sharifiaghdam M, Shaabani E, Faridi-Majidi R, De Smedt SC, Braeckmans K, Fraire JC. Macrophages as a therapeutic target to promote diabetic wound healing. Mol Therapy: J Am Soc Gene Therapy. 2022;30(9):2891–908.

    CAS 

    Google Scholar
     

  • Dixon D, Edmonds M. Managing diabetic foot ulcers: pharmacotherapy for wound healing. Drugs. 2021;81(1):29–56.

    CAS 
    PubMed 

    Google Scholar
     

  • Chang M, Nguyen TT. Strategy for treatment of infected diabetic foot ulcers. Acc Chem Res. 2021;54(5):1080–93.

    CAS 
    PubMed 

    Google Scholar
     

  • Uemura A, Fruttiger M, D’Amore PA, De Falco S, Joussen AM, Sennlaub F, Brunck LR, Johnson KT, Lambrou GN, Rittenhouse KD, Langmann T. VEGFR1 signaling in retinal angiogenesis and microinflammation. Prog Retin Eye Res. 2021;84:100954.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jaipersad AS, Lip GY, Silverman S, Shantsila E. The role of monocytes in angiogenesis and atherosclerosis. J Am Coll Cardiol. 2014;63(1):1–11.

    CAS 
    PubMed 

    Google Scholar
     

  • Daseke MJ 2nd, Tenkorang MAA, Chalise U, Konfrst SR, Lindsey ML. Cardiac fibroblast activation during myocardial infarction wound healing: fibroblast polarization after MI. Matrix Biology: J Int Soc Matrix Biology. 2020;91–2:109–116.

  • Ginn SL, Amaya AK, Alexander IE, Edelstein M, Abedi MR. Gene therapy clinical trials worldwide to 2017: an update. J Gene Med. 2018;20(5):e3015.

    PubMed 

    Google Scholar
     

  • Smith RH. Adeno-associated virus integration: virus versus vector. Gene Ther. 2008;15(11):817–22.

    CAS 
    PubMed 

    Google Scholar
     

  • Niwano K, Arai M, Koitabashi N, Watanabe A, Ikeda Y, Miyoshi H, Kurabayashi M. Lentiviral vector-mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats. Mol Therapy: J Am Soc Gene Therapy. 2008;16(6):1026–32.

    CAS 

    Google Scholar
     

  • Ribeil JA, Hacein-Bey-Abina S, Payen E, Magnani A, Semeraro M, Magrin E, Caccavelli L, Neven B, Bourget P, Nemer WE, Bartolucci P, Weber L, Puy H, Meritet JF, Grevent D, Beuzard Y, Chrétien S, Lefebvre T, Ross RW, Negre O, Veres G, Sandler L, Soni S, de Montalembert M, Blanche S, Leboulch P, Cavazzana M. Gene therapy in a patient with sickle cell disease. N Engl J Med. 2017;376(9):848–55.

    CAS 
    PubMed 

    Google Scholar
     

  • Rangarajan S, Walsh L, Lester W, Perry D, Madan B, Laffan M, Yu H, Vettermann C, Pierce GF, Wong WY, Pasi KJ. AAV5-Factor VIII gene transfer in severe hemophilia A. N Engl J Med. 2017;377(26):2519–30.

    CAS 
    PubMed 

    Google Scholar
     

  • Greenberg B, Butler J, Felker GM, Ponikowski P, Voors AA, Desai AS, Barnard D, Bouchard A, Jaski B, Lyon AR, Pogoda JM, Rudy JJ, Zsebo KM. Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial. Lancet (London England). 2016;387(10024):1178–86.

    CAS 
    PubMed 

    Google Scholar
     

  • Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H, Hajjar RJ. Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation. 2011;124(3):304–13.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Valdmanis PN, Lisowski L, Kay MA. rAAV-mediated tumorigenesis: still unresolved after an AAV assault. Mol Therapy: J Am Soc Gene Therapy. 2012;20(11):2014–7.

    CAS 

    Google Scholar
     

  • Louis Jeune V, Joergensen JA, Hajjar RJ, Weber T. Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy. Hum Gene Therapy Methods. 2013;24(2):59–67.

    CAS 

    Google Scholar
     

  • Wang Z, Zhu T, Qiao C, Zhou L, Wang B, Zhang J, Chen C, Li J, Xiao X. Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat Biotechnol. 2005;23(3):321–8.

    CAS 
    PubMed 

    Google Scholar
     

  • Tang Q, Lu B, He J, Chen X, Fu Q, Han H, Luo C, Yin H, Qin Z, Lyu D, Zhang L, Zhou M, Yao K. Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration. Biomaterials. 2022;280:121320.

    CAS 
    PubMed 

    Google Scholar
     

  • Bialik M, Kuras M, Sobczak M, Oledzka E. Achievements in thermosensitive gelling systems for rectal administration. Int J Mol Sci. 2021;22(11).

  • Dethe MR, Ahmed PAH, Agrawal M, Roy U, Alexander A. PCL-PEG copolymer based injectable thermosensitive hydrogels. J Control Release. 2022;343:217–36.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aliakbari F, Marzookian K, Parsafar S, Hourfar H, Nayeri Z, Fattahi A, Raeiji M, Boroujeni NN, Otzen DE, Morshedi D. The impact of hUC MSC-derived exosome-nanoliposome hybrids on α-synuclein fibrillation and neurotoxicity. Sci Adv. 2024;10(14):eadl3406.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guo G, Tan Z, Liu Y, Shi F, She J. The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer. Stem Cell Res Ther. 2022;13(1):138.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang S, Liang X, Song J, Li C, Liu A, Luo Y, Ma H, Tan Y, Zhang X. A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6. Stem Cell Res Ther. 2021;12(1):315.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bi Y, Qiao X, Liu Q, Song S, Zhu K, Qiu X, Zhang X, Jia C, Wang H, Yang Z, Zhang Y, Ji G. Systemic proteomics and MiRNA profile analysis of exosomes derived from human pluripotent stem cells. Stem Cell Res Ther. 2022;13(1):449.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Z, Mi T, Jin L, Li M, Zhanghuang C, Wang J, Tan X, Lu H, Shen L, Long C, Wei G, He D. Comprehensive proteomic analysis of exosome mimetic vesicles and exosomes derived from human umbilical cord mesenchymal stem cells. Stem Cell Res Ther. 2022;13(1):312.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang K, Li D, Wang M, Xu Z, Chen X, Liu Q, Sun W, Li J, Gong Y, Liu D, Shao C, Liu Q, Li X. Exposure to blue light stimulates the proangiogenic capability of exosomes derived from human umbilical cord mesenchymal stem cells. Stem Cell Res Ther. 2019;10(1):358.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cao T, Chen H, Huang W, Xu S, Liu P, Zou W, Pang M, Xu Y, Bai X, Liu B, Rong L, Cui ZK, Li M. hUC-MSC-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits Β3 and Γ2 of the GABA(A) receptor. Theranostics. 2022;12(7):3057–78.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lu T, Zhang J, Cai J, Xiao J, Sui X, Yuan X, Li R, Li Y, Yao J, Lv G, Chen X, Chen H, Zeng K, Liu Y, Chen W, Chen G, Yang Y, Zheng J, Zhang Y. Extracellular vesicles derived from mesenchymal stromal cells as nanotherapeutics for liver ischaemia-reperfusion injury by transferring mitochondria to modulate the formation of neutrophil extracellular traps. Biomaterials. 2022;284:121486.

    CAS 
    PubMed 

    Google Scholar
     

  • Galipeau J, Sensébé L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22(6):824–33.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peng C, Trojanowski JQ, Lee VM. Protein transmission in neurodegenerative disease. Nat Reviews Neurol. 2020;16(4):199–212.

    CAS 

    Google Scholar
     

  • Deng H, Dong A, Song J, Chen X. Injectable thermosensitive hydrogel systems based on functional PEG/PCL block polymer for local drug delivery. J Control Release. 2019;297:60–70.

    CAS 
    PubMed 

    Google Scholar
     

  • Pan W, Wu B, Nie C, Luo T, Song Z, Lv J, Tan Y, Liu C, Zhong M, Liao T, Wang Z, Yi G, Zhang L, Liu X, Li B, Chen J, Zheng L. NIR-II responsive nanohybrids incorporating thermosensitive hydrogel as sprayable dressing for Multidrug-Resistant-Bacteria infected wound management. ACS Nano. 2023;17(12):11253–67.

    CAS 
    PubMed 

    Google Scholar
     

  • Li S, Yang C, Li J, Zhang C, Zhu L, Song Y, Guo Y, Wang R, Gan D, Shi J, Ma P, Gao F, Su H. Progress in pluronic F127 derivatives for application in wound healing and repair. Int J Nanomed. 2023;18:4485–505.

    CAS 

    Google Scholar
     

  • Chao Y, Xu L, Liang C, Feng L, Xu J, Dong Z, Tian L, Yi X, Yang K, Liu Z. Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint Blockade imparts potent antitumour responses. Nat Biomedical Eng. 2018;2(8):611–21.

    CAS 

    Google Scholar
     

  • Lv Q, Wang Y, Tian W, Liu Y, Gu M, Jiang X, Cai Y, Huo R, Li Y, Li L, Wang X. Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis. J Nanobiotechnol. 2023;21(1):419.

    CAS 

    Google Scholar
     

  • Peralta C, Jiménez-Castro MB, Gracia-Sancho J. Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu. J Hepatol. 2013;59(5):1094–106.

    PubMed 

    Google Scholar
     

  • Jorgensen AN, Rashdan NA, Rao KNS, Delgadillo LF, Kolluru GK, Krzywanski DM, Pattillo CB, Kevil CG, Nam HW. Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells. Redox Biol. 2024;70:103085.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hu Z, Wang D, Gong J, Li Y, Ma Z, Luo T, Jia X, Shi Y, Song Z. MSCs deliver Hypoxia-Treated mitochondria reprogramming acinar metabolism to alleviate severe acute pancreatitis injury. Adv Sci (Weinh). 2023;10(25):e2207691.

    PubMed 

    Google Scholar
     

  • Miettinen TP, Björklund M. Mitochondrial function and cell size: an allometric relationship. Trends Cell Biol. 2017;27(6):393–402.

    CAS 
    PubMed 

    Google Scholar
     

  • Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022;55(8):1370–e13858.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chakradhar S. Puzzling over privilege: how the immune system protects-and fails-the testes. Nat Med. 2018;24(1):2–5.

    PubMed 

    Google Scholar
     

  • Park EH, Kim YJ, Yamabe N, Park SH, Kim HK, Jang HJ, Kim JH, Cheon GJ, Ham J, Kang KS. Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell. J Ginseng Res. 2014;38(1):22–7.

    PubMed 

    Google Scholar
     

  • Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H. Microglia-Mediated neuroinflammation: A potential target for the treatment of cardiovascular diseases. J Inflamm Res. 2022;15:3083–94.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ablasser A, Chen ZJ. cGAS in action: expanding roles in immunity and inflammation. Science. 2019;363(6431).

  • Gulen MF, Samson N, Keller A, Schwabenland M, Liu C, Glück S, Thacker VV, Favre L, Mangeat B, Kroese LJ, Krimpenfort P, Prinz M, Ablasser A. cGAS-STING drives ageing-related inflammation and neurodegeneration. Nature. 2023;620(7973):374–80.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang HJ, Ran HF, Yin Y, Xu XG, Jiang BX, Yu SQ, Chen YJ, Ren HJ, Feng S, Zhang JF, Chen Y, Xue Q, Xu XY. Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling. Acta Pharmacol Sin. 2022;43(7):1670–85.

    CAS 
    PubMed 

    Google Scholar
     

  • He Y, Wang H, Lin S, Chen T, Chang D, Sun Y, Wang C, Liu Y, Lu Y, Song J, Li S, Xu W, Lin Y, Zheng Y, Zhou X, Huang Q, Huang M. Advanced effect of Curcumin and Resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K/AKT/mTOR and HIF-1/VEGF cascade. Biomed Pharmacother. 2023;165:115279.

    CAS 
    PubMed 

    Google Scholar
     

  • Yamashita M, Niisato M, Kawasaki Y, Karaman S, Robciuc MR, Shibata Y, Ishida Y, Nishio R, Masuda T, Sugai T, Ono M, Tuder RM, Alitalo K, Yamauchi K. VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury. Eur Respir J. 2022;59(4).

  • Meng LB, Zhang YM, Shan MJ, Qiu Y, Zhang TJ, Gong T. Pivotal micro factors associated with endothelial cells. Chin Med J. 2019;132(16):1965–73.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xiong Y, Chen L, Liu P, Yu T, Lin C, Yan C, Hu Y, Zhou W, Sun Y, Panayi AC, Cao F, Xue H, Hu L, Lin Z, Xie X, Xiao X, Feng Q, Mi B, Liu G. All-in-One: multifunctional hydrogel accelerates oxidative diabetic wound healing through Timed-Release of exosome and fibroblast growth factor, small (Weinheim an der Bergstrasse. Germany). 2022;18(1):e2104229.


    Google Scholar
     

  • Liu K, Gao X, Hu C, Gui Y, Gui S, Ni Q, Tao L, Jiang Z. Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress. Redox Biol. 2022;56:102460.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fan X, Wu X, Yang F, Wang L, Ludwig K, Ma L, Trampuz A, Cheng C, Haag R. A Nanohook-Equipped Bionanocatalyst for localized Near-Infrared-Enhanced catalytic bacterial disinfection. Angew Chem Int Ed Engl. 2022;61(8):e202113833.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche. Sci Immunol. 2024;9(91):eadh0152.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li Z, Liu J, Song J, Yin Z, Zhou F, Shen H, Wang G, Su J. Multifunctional hydrogel-based engineered extracellular vesicles delivery for complicated wound healing. Theranostics. 2024;14(11):4198–217.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Y, Lin Q, Zhang H, Wang S, Cui J, Hu Y, Liu J, Li M, Zhang K, Zhou F, Jing Y, Geng Z, Su J. M2 macrophage-derived exosomes promote diabetic fracture healing by acting as an Immunomodulator. Bioact Mater. 2023;28:273–83.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu H, Zhang Q, Wang S, Weng W, Jing Y, Su J. Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: advances and perspectives. Bioact Mater. 2022;14:169–81.

    CAS 
    PubMed 

    Google Scholar
     

  • Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, Hei Y, Xian P, He Z, Li Z, Li N, Long Q. MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. Biomaterials. 2020;257:120264.

    CAS 
    PubMed 

    Google Scholar
     

  • Yang KJ, Choi WJ, Chang YK, Park CW, Kim SY, Hong YA. Inhibition of Xanthine oxidase protects against diabetic kidney disease through the amelioration of oxidative stress via VEGF/VEGFR Axis and NOX-FoxO3a-eNOS signaling pathway. Int J Mol Sci. 2023;24(4).



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