“As a proof of concept, it is impressive,” says Keren Ladin, a bioethicist who has focused on organ transplantation and perfusion at Tufts University. “These are early days.”
It might not sound like much, but 24 hours is a long time for an organ to be out of the body. Maintaining a donated uterus for that long could expand the options for uterus transplant, a fairly new procedure offered to some people who want to be pregnant but don’t have a functional uterus, says Gerald Brandacher, professor of experimental and translational transplant surgery at the Medical University of Innsbruck in Austria.
“It is better than what we currently have, because we have only a couple of hours,” he says. So far, most uterus transplants have been planned operations involving organs from living donors. A technology like this could allow for the use of more organs from deceased donors, he says.
That work is “not in the immediate pipeline” for the team in Spain, says Santamaria. “We are working on other problems.”
Pregnancy in the lab?
Santamaria, González, and their colleagues are more interested in using sustained human uteruses for research.
They’ve mounted a camera to a wall in the corner of the room, pointed at their machine. It allows the team to monitor “Mother” remotely, and to check if any valves disconnect. (That happened once before—a spike in pressure caused the blood bag to come loose, spilling a liter of blood on the floor, Santamaria says.)
They’d like to be able to keep their uteruses alive for around 28 days to study the menstrual cycle and disorders that affect the uterus, like endometriosis and fibroids.
