Advanced oxidation processes (AOPs) play a pivotal role in purifying water contaminants and securing drinking water safety. Transition metal-based materials are highly effective AOP catalysts, while their applications are limited by their poor stability in the oxidative environment. In this study, we developed the composite catalyst, molybdenum disulfide/ferric oxide (MoS2/Fe3O4), to evaluate the catalytic performance and explore the underlying mechanisms in peroxymonosulfate activation. The powder composite was successfully loaded onto an engineered wood substrate, creating a monolith wood@MoS2/Fe3O4 composite for large-scale practical applications. The engineered bulk catalyst exhibits exceptional versatility and stability in wastewater treatment, maintaining nearly 100% removal efficiency over a continuous operation of 144 hours. These findings underscore the significant potential of wood-loaded nanomaterials for cost-effective wastewater treatment.